Electrospinning can be used to produce nanoscale polymeric fibers. This fibrous structure inherent in the electrospun scaffolds provides large surface area and high porosity that allow the scaffolds to be potentially used for various applications including tissue engineering, wound dressing and filtration. However, it is difficult to control microstructure morphology of electrospun scaffolds, which is sensitive to various parameters. This paper reviews ways to control three important microstructure morphologies including fiber diameter, the formation of beads and pores. The review shows that electrospinning parameters including polymer solution concentration, voltage, tip-collector distance, solution feed rate, solvent selection, addition of salt, polymer molecular weight and humidity affect the scaffold morphology. Knowledge of complex interactions of these interrelated variables is still lacking. The review gives insight for the robust production of electrospinning technique in tissue engineering application that requires a control of microstructure morphology.